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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

“还有大批人没有统计进来,”胡润对英国《金融时报》表示,“两周前我在北京拜访了这家投资公司。一下午的时间,我就发掘出了30个登上今年富豪榜的人。他们去年还不在我们的视线内。”
The U.S. $10 bill will feature the portrait of a notable U.S. woman by 2020.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

狄更斯在《双城记》中描写法国大革命时,距离事件发生已有近一个世纪。而我则是在今年12月就回顾盘点这一年。因此,我在此描述的某些趋势,可能将在可预见的未来继续存在,而另一些趋势则可能已经开始减弱。作为当今时代“最哗众取宠的权威人士”之一,我只要求各位在阅读这篇评论文章时记住一点:过去的业绩并不能保证将来的表现。
1. Peaceful Era

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

stressful

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

With the release of his book Conscious Capitalism, Whole Foods (WFM, Fortune 500) CEO John Mackey got business leaders thinking about a compelling idea: Companies work best when they create value for all their stakeholders -- not just investors. According to Mackey, key stakeholders include customers, employees, suppliers, society, and the environment. Highlighting companies like Costco, Southwest Airlines (LUV,Fortune 500), and Google (GOOG, Fortune 500), Mackey demonstrates that thinking about more than just the bottom line builds stronger and more efficient businesses.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

"Overall this ranking of Asia's best 300 universities proves what a dynamic, diverse and competitive higher education region the continent is becoming -- and China is a key part of that development," said Baty.
单词affected 联想记忆:
Set in 1950's London, Reynolds Woodcock is a renowned dressmaker whose fastidious life is disrupted by a young, strong-willed woman, Alma, who becomes his muse and lover.
中俄双方经贸合作的潜力很大,互补性很强,双方所达成的经贸关系目标是可以实现的。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Among the top 50 IT tycoons, five were born in the 1980s, including 33-year-old Cheng Wei, chief executive officer of Didi Chuxing.
《美国谍梦》(The Americans),FX,1月28日播出。这部剧精彩地将冷战间谍惊悚剧与家庭剧融为一体,第三季一开始,潜伏在华盛顿的克格勃小队感受到了苏联的阿富汗战争的压力。弗兰克·兰格拉(Frank Langella)加入演员阵容,饰演剧中夫妻间谍的新联系人,取代了玛戈·马丁代尔(Margo Martindale)饰演的克劳迪娅(Claudia)。顺便说一句,八天后NBC即将首播的《忠诚》(Allegiance)是讲述潜伏在美国的俄罗斯间谍的。哈。
adv. 有意地,故意地
It is just a common sense that no one wants to see chaos at his doorstep.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

“What happens if one of these Airbnb guests starts a fire?” asked Phyllis H. Weisberg, chairwoman of the Cooperative and Condominium Law Committee at the New York City Bar Association. “Who’s paying for that?”

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

《老友记》大部分剧集拍摄之时,手机和Google都还未普及,剧中的服装和道具现在看来也有些过时,但是,剧中的主题却依旧深得现在年轻观众的心。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

As a brand, Acura sold 167,843 cars and trucks last year, a 1.5% increase. Lexus, Toyota’s premium brand, was up 13.7%; BMW was up 9.8%, Audi was up 15.2% and Mercedes-Benz was up 6.5% in a U.S. market that was very favorable for luxury vehicle manufacturers.
But I expect other banks to follow suit. Any effort to keep good people fresh and engaged, without paying them more, should be up for consideration.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

1、超级自信。邦德的超级自信让他不仅更加性感,而且工作更出色。与理性和客观相比,多一些自信往往收获更多(自负时人人感觉都不错)。无论男女都不喜欢谦逊的人。邦德有着实干家的品质:作为特种部队成员,他与普通人不同,具有非凡的自信(又称“自欺性提高”),并且情绪更稳定、更富弹性。
adolescent

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

《三生三世十里桃花》的豆瓣评分为6.4分,一些网友认为,这部剧的爱情戏码太多了。
从1970年到今天,世界各地的文盲减少了50%。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

WTF.2: They Believe You Can Fly
The charges of Russian hacking and Mr Trump’s evident defects of experience, judgment and character show that the college has not proved the bulwark Mr Hamilton hoped for.
莎拉奥康纳(Sarah O'Connor)是就业记者
Detectives have laid charges, but said they will not release the details of the offenses until Friday when both the 18-year-old and the youth are expected to appear in court.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

During the same period, Braziland Russia slashed their holdings to USD 261.7 billion and USD 108.9 billion,respectively.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 愿奋斗者们住有所居,心有所属
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

“Yao represents the new wave of wealth creation by financial investments in China,” said Rupert Hoogewerf, who compiles the annual list.
'I think South Korea has a very rigorous and narrow definition of beauty because we’re an ethnically homogenous society and everyone looks pretty much the same. It is also related to low self-esteem.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Notably, among the nine schools ranked for the first time, WP Carey School of Business at the Arizona State University is the first US institution to take part in the ranking, having entered at 82.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

金奇(James Kynge)

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

1月份出口同比下滑6.6%至1.14万亿元人民币,而此前在去年12月份则曾增长2.3%。经济学家原本预计会增长3.6%。这是自去年7月下滑8.9%以来,出口出现的最大跌幅。
Goldman Sachs will pay out big bonuses, be publicly vilified for a month and then go quietly back to printing profits.
['p?li?]
Allianz

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

10月份,南非减持美国政府债券到103亿美元。
infection
Leading the pack of the best airlines for holiday travel is Hawaiian Airlines, followed by another Pacific Coast-focused carrier, Alaska Airlines. Conversely, the worst airline for holiday travel is New York-based JetBlue Airways, with ExpressJet, a regional carrier, coming in next to last, according to the FlightAware data.
去年12月,中国工业利润降幅达到创纪录的8%,显示中国有针对性的刺激计划未能抑制工业放缓,而工业是中国经济的主要推动力。
‘Our hope is that the Worst Passwords of the Year list will cause people to take steps to protect themselves online.’

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

用户说,语音信息的传输速度很快,可以在微信平台上对话。但和微软(Microsoft Corp.)的Skype等免费语音应用不同的是,在微信上还可以另选时间回复别人发来的语音信息。北京微信用户Robin Wang说,我可以决定什么时候回复,以及回不回复。
These collaborations signal a moment where the cradle of innovation and the arbiters of fashion are finally embracing one another, says L2 research director Colin Gilbert. Style is not the only missing piece to the wearable puzzle, but it’s something to look forward to, Gilbert says. More than half of the report’s respondents want devices that feel more like jewelry while 62 percent would like more than wrist-worn devices.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

近日,新一期福布斯世界富豪排行榜揭晓,比尔·盖茨在近22年内第17次问鼎榜首。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

5.匈牙利德布勒森

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 我国城乡低保标准再提高
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

That was in line with last month’s manufacturing PMIs, which showed an uptick in sector activity,
可穿戴设备公司Atlas Wearables创始人彼得o李表示,电池技术和用户的保守是可穿戴市场面临的两大障碍。他说,在一些情况下,电池技术需要有足够大的改进才能实现足以激发用户兴趣的体验,而在穿戴时间、充电时间、处理能力和产品特点上,各家公司也需要做出平衡。
凡是这家汽车服务公司的忠实员工在效力满10年后,都可获得一份奖励:在佛罗里达州波卡拉顿的一处度假胜地欢度周末(此地距该公司总部仅15分钟车程)。这项福利此后每5年都可以享受一次。
LONDON — In the 1970s, the British comedian Tommy Cooper used to tell a joke about asking an auction house to value a violin and a painting that he had discovered in an attic. The good news, he was told, is that they were made by Stradivarius and Rembrandt. The bad news was that the painting was by Stradivarius and the violin was by Rembrandt.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
From the themed collection: 房地产行业薪酬普遍上涨
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

"Shanghai has taken a series of tough measures to curb population growth since 2014, including renovating urban villages and regulating group renting," Zhou Haiwang, an expert with the Shanghai Academy of Social Sciences, told the Global Times.
departure
我们错了——最终睾丸还是与免疫系统有关联的。研究人员发现了“一扇非常小的门”使睾丸可以向免疫系统发送单向信号,这解释了为什么一些男性会被不孕症所困扰,也解释了某些癌症疫苗一直失败的原因。
We will perform with a strong work ethic, sense of responsibility, and enterprising spirit.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

4.无人驾驶的汽车
1)Thank You: Common courtesy? Sure. But tell me this: When was the last time you forgot (or rejected) gratitude? Whether given in private or public, a sincere ‘thanks’ creates goodwill. Don’t forget your mother’s advice: “Say please.” People are always happier doing a favor than taking an order.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

产险公司利润同比下降43.49%,至336.57亿元人民币。寿险公司利润下降65.60%,至541.84亿元人民币,再保险公司利润下降58.79%,至30.68亿元人民币。
糟糕的婚姻会导致早逝
时间:2009-11-19 编辑:vicki
政府确实管了一些不该管、也不应属于自己管的事情,它束缚了市场主体的手脚,降低了行政效率,甚至影响了政府的公信力。
sincerely

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

The Great Recession had devastating effects across the U.S. and few places were as hard hit as Arizona. The state was booming on the strength of its tourism and real estate markets during the 2000s. Median home prices jumped 70% between 2003 and 2006—only Nevada had bigger gains—fueling more building and construction jobs. Monthly unemployment was at 3.5% through much of 2007. But then the bottom fell out. Home prices plummeted more than 50% from their peak and 6% Arizona properties received foreclosure filings in 2009. Unemployment stubbornly remained in double-figures for most of 2009 and 2010 and only Nevada lost a higher percentage of jobs over the last five years. Household incomes declined at the fastest rate in the country since 2008.
[dr?ft]
as加强+soc社会+ion→社团;联合

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Slow growth around the world won't hurt the U.S. all that much. American exports might flatten out or even dip, but that would be offset by lower imports of petroleum because of sinking oil prices. So the trade deficit is unlikely to get further out of whack.
We are a group of twelve and thirteen-year-olds from Canada trying to make a difference:Vanessa Suttie, Morgan Geisler, Michelle Quigg and me. We raised all the money ourselves to come six thousand miles to tell you adults you must change your ways. Coming here today, I have no hidden agenda. I am fighting for my future. 我们是一个十三四岁的小群体,我们想改变些什么:Vanessa Suttie, Morgan Geisler, Michelle Quigg和我。我们自己挣钱支持我们来到这里,旅行5000英里只为告诉你们成年人,你们必须改变你们的生活方式。今天我来到这里,我背后没有任何经纪人,我们为我们的未来而战。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

在观影从始至终,我都在问自己一个问题:这部电影到底在讲什么……这部电影的主题仿佛一锅杂烩,并不明晰。我希望制片人也在问同样的问题。
Whiteness means being part of the group whose appearance, traditions, religion and even food are the default norm. It’s being a person who, by unspoken rules, was long entitled as part of “us” instead of “them.”
"Hard to believe so many doctors lied in the papers. Can patients still trust them to help us treat diseases?" wrote one Sina Weibo user.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

单词deputy 联想记忆:
The deal makes a millionaire of 17-year-old Mr D’Aloisio, who taught himself to write software aged 12 and will join Yahoo’s London office while he continues his studies at school.
Earlier on Tuesday Mr Rutte had issued a call for calm in the dispute with Turkey.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Lady Gaga以5.9千万位列第四,其后是5.45千万的碧昂斯。前者在统计期间演出了66场,也靠与范思哲和MAC的合约获得收入,同时还有她自己的黑色香水。后者与其老公Jay Z的On The Run巡回演唱会通过19天(北美日期),赚得了超过10千万,创造了能与滚石相比较的第一对音乐界夫妻档夜平均的神话。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

007系列电影主题曲第四名:汤姆·琼斯--《霹雳弹》

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

The dollar value of outbound shipments from China rose 12.3 per cent year on year in November, lifting from a revised pace of 6.8 per cent in October, and smashing a median forecast of 5 per cent from economists polled by Reuters.
赖床有了新理由

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 央行降准释放7000亿流动性
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

The first view is that the price is inherently cyclical. What has come down must go back up again and the deeper the trough the higher the next mountain.
NBS senior statistician Sheng Guoqing attributed the slowdown mainly due to a 1.4-percent decline in food prices, which were down for the first time in 15 years.
pandemic
New Chinese firms on the list include Vanke, China Railway Engineering Corporation (CREC) and China Taiping Insurance.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

与此同时,微信恐怕也是腾讯吸引海外用户潜力最大的产品。Forrester的分析师Bryan Wang说,他看到新加坡、印度的同事和朋友也开始出现在了自己的微信好友列表中。
扎实推进“一带一路”建设。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Song “Happiness” (Mao A’Min)
vt. 起草,征

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

[slu:]

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

以下10种妖魔就像无人机一样,瞄准了股市、债市和世界经济:
7月,美国国家航空航天局(NASA)宣布发现了一颗类地行星,激发了中国人的想象。
Ladies and gentlemen, may I welcome you to the Bad Manners Awards 2016?
出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

为了让世界都关注濒危物种和中国成都大熊猫基地,演出者们全力表演,节目精彩令人难以忘怀。他们不仅给伦敦市民带去了乐趣,还与基地大使、自然主义者奈杰尔-马文一同去学校向孩子们宣扬熊猫保护的理念。
China has continued to synchronize enterprises and institutions to raise the basic pension for over 100m retirees in 2017.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

伊纳里图表示:“我差点忘记感谢所有参与拍摄的美国印第安人了,没有他们,这部电影不可能拍摄出来。我能够和这些人一起活着拍完这部电影,心中的惊喜和骄傲难以用语言表达。”
Heatwaves around the world, including one in India that led to more than 2,000 deaths and another in Iraq that saw the mercury top 50C, helped push temperatures 1C above pre-industrial levels for the first time, US and UK researchers said.
A schoolgirl aged 11 has been honoured as "America's top young scientist" for inventing a quick, low-cost test to detect lead-contaminated water.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 仿古砖+现代风“砖”攻80后90后
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Since April 2007, the value of the top 100 brands has increased by 106 per cent. That compares with a 61 per cent rise in the S&P 500 and growth of 21 per cent in the MSCI world index over the same period.
Mr Mallaby accepted the award at a dinner in London on November 22, where the guest speaker was Dido Harding, chief executive of TalkTalk, the UK telecoms group.
Consoles: PlayStation 4

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

But the runaway winner was Ford CEO Mark Fields, who began the year with the depressing news that his company was “transitioning from an auto company to an auto company and a mobility company”. He then went on to declare: “Heritage is history with a future.” He was so chuffed with this, he said it more than once. On hearing it repeated, I’ve concluded it is less gnomic than downright moronic. Mr Fields is thus my new Chief Obfuscation Champion.
节目20 小品《今天的幸福2》,沈腾 马丽 杜晓宇 王琦

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

不像那些狂热追星的小女孩,玛蒂认为她一直都能保持着冷静的头脑,即使在格莱美颁奖典礼这种场合。因为她将自己视为一个明星,所以她需要表现得体。
The economy has registered a slower but stable performance with good momentum for growth.
有抱负的年轻领导人已经更注重利用自己的影响力,而不是试图凭借其职位或头衔所带来的权威来发号施令。很多人已经拥有了领导经验——不是通过在老牌机构中的晋升,而是通过领导自下而上的运动和志愿组织、或是打造自己的初创公司。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

There was no immediate word from the Romney camp on the reported results。
约翰奥瑟兹(John Authers)

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

All this is happening before our eyes and yet we act as if we have all the time we want and all the solutions. I'm only a child and I don't have all the solutions, but I want you to realise, neither do you! 所有这一切就发生在我们眼前,然而我们还是一直向大自然无度索取我们所需要的。我仅仅是个孩子,我不知道该怎么办。 但我们这些孩子——这个星球的未来需要让您认识到,您不能说没办法!
事实上,贷款给Seppenwolde的那些机构一个荷兰盾都没损失。他们在几周内就清空了全部的东印度股票,收回了所有贷款。
The circular also stressed zero tolerance for cheating.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 北京冬奥村赛后将变身人才公租房
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

周二在上海举办的中国国际机器人产业发展高峰论坛称,2017年,工业机器人的销量和增速均创新高。在这些工业机器人当中,有37825台为国产制造,同比增长29.8%。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

We will make solid efforts to pursue the Belt and Road Initiative.
adj. 全球性的,全世界的,球状的,全局的

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

GM Masai Ujiri struck twice to position Toronto for a second trip to the East finals, nabbing Ibaka from the Magic and Tucker from the Suns.
Their inclusion has come at the expense mainly of European companies, signalling the shift in economic power towards the east. There is only one Indian brand in the top 100 ranking — HDFC Bank. Russian, Mexican and Brazilian brands have fallen out of the ranking in the past few years — a sober reflection of the changing fortunes of these emerging markets.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

['s?r?git]
3. 3M

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

11. “The Black Panthers: Vanguard of the Revolution” (Stanley Nelson)
更多精彩内容请关注微信公众号、新浪微博:篮球英文堂

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

"Machines will be stronger and smarter than human beings, but they will never be wiser," he said, "because one thing's for sure: Wisdom, soul and heart are things that only human beings possess, and machines can never enjoy failure, success, friendship or love."

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

3. Jeonju, South Korea-Hundreds of traditional Korean houses remain in central Jeonju's Hanok village.
n. 准学士学位获得
6. China will also soonmake further announcements regarding affordable housing and more accessiblehealthcare. The country still needs 75 million more $75,000 housing unitsand it will begin breaking ground on them, in earnest, in 2014. Theseinvestments, particularly in health care, will effectively become self-funded,allowing average Chinese consumers to consider saving less, and spending more. It will drive longevity and years of productive employment.
UK schools account for more than a third of all graduates from the top 50 pre-experience programmes and not only attracted nearly half of all female students but also almost half of all international students. Indeed, 94 per cent of students enrolled in a UK MiF pre-experience programme in 2014 were from overseas. About 85 per cent of these students were from outside the European Economic Area, including 55 per cent of the overall number from mainland China.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

We learned about fetal surgery’s potential to change lives.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

[iks'tr?v?g?nt]
大宗农产品投机交易一直是今年市场波动的一个特点,荷兰合作银行预测,这种趋势将继续。
*剧情类最佳客串女演员:玛格?马丁戴尔(Margo Martindale),《美国谍梦》(The Americans)

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Sandy has caused large-scale damage, with more possibly to come.
Mr. Sissako is both an indispensable political filmmaker and one of the great poets of contemporary cinema. His portrait of life under jihadi rule in northern Mali is brutal and shocking, but also gentle, generous and surprisingly funny. Mr. Sissako does not humanize violent extremists so much as demonstrate that they already belong to the species and reflect part of our common, tragic nature. But his movie also insists that the only effective and ethically serious way to oppose fanaticism is with humanism. Which is to say with irony, with decency and, perhaps above all, with art. (Read the review.)

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

[k?:]
[in'tendid]

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

But if the U.S. can avert that Washington-made crisis, the outlook for workers finding jobs is actually looking pretty good for next year. For one thing, the damage of superstorm Sandy will have to be repaired, meaning jobs in construction and retail. Businesses, meanwhile, which have held off investing and hiring because of uncertainty over the fiscal outlook, might finally open their wallets. That means more jobs, too.[qh]

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

该报告还指出,那些在经济衰退期间不得已裁减支持型岗位的公司,也会“补充新人,以帮助各部门提高效率,提升生产力水平。”对于求职者而言,这一趋势无疑预示着一个美好的新年。
众所周知,中国国家主席习近平也是一个足球迷,他曾多次表达了自己对中国足球发展的支持。
时间长度:24个月

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

塞舌尔
因此,D型人格的人并不是缺乏社交兴趣,而是可能对别人感兴趣,但又害怕接近别人,因为他们害怕被拒绝。
[ri'li:s]
Pink, LeBron James, Selena Gomez, Ian Somerhalder, Jay-Z and Beyonce, Ben Affleckalso made the list.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

After the officials realized what had happened, they tried to get on stage immediately. But the news was broken to the La La Land cast and crew after they had started their acceptance speeches.
以下十条就是你找工作时可能露出的“马脚”

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 三安打响2017LED涨价“第一枪”
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

“Since these developments will not fade overnight, there is little hope for a trade revival in 2017,” says Mr Leering.
vt. 监禁,下狱
"It is a truly a global phenomenon in which people, due to lack of opportunities, have to leave their families behind to provide for them," said Pedro De Vasconcelos, IFAD policy advisor and author of the report.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 上海加梯新政 感受城市温度
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About this collection

国家统计局日前在其网站发布了上述数据,称这是科技研发经费增速连续4年下滑后的首次回升。
保罗·乔治,克里斯·保罗,卡梅罗·安东尼,戈登·海沃德,吉米·巴特勒,德里克·罗斯,保罗·米尔萨普,J·J·雷迪克,埃里克·布莱索,德怀特·霍华德……自去年以来,换了东家的球员名单还在不断增加。

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