Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
The U.S. $10 bill will feature the portrait of a notable U.S. woman by 2020.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
1. Peaceful Era
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
With the release of his book Conscious Capitalism, Whole Foods (WFM, Fortune 500) CEO John Mackey got business leaders thinking about a compelling idea: Companies work best when they create value for all their stakeholders -- not just investors. According to Mackey, key stakeholders include customers, employees, suppliers, society, and the environment. Highlighting companies like Costco, Southwest Airlines (LUV,Fortune 500), and Google (GOOG, Fortune 500), Mackey demonstrates that thinking about more than just the bottom line builds stronger and more efficient businesses.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
"Overall this ranking of Asia's best 300 universities proves what a dynamic, diverse and competitive higher education region the continent is becoming -- and China is a key part of that development," said Baty.
Set in 1950's London, Reynolds Woodcock is a renowned dressmaker whose fastidious life is disrupted by a young, strong-willed woman, Alma, who becomes his muse and lover.
Trends and targets in antiviral phototherapy
Among the top 50 IT tycoons, five were born in the 1980s, including 33-year-old Cheng Wei, chief executive officer of Didi Chuxing.
《美国谍梦》(The Americans)，FX，1月28日播出。这部剧精彩地将冷战间谍惊悚剧与家庭剧融为一体，第三季一开始，潜伏在华盛顿的克格勃小队感受到了苏联的阿富汗战争的压力。弗兰克·兰格拉(Frank Langella)加入演员阵容，饰演剧中夫妻间谍的新联系人，取代了玛戈·马丁代尔(Margo Martindale)饰演的克劳迪娅(Claudia)。顺便说一句，八天后NBC即将首播的《忠诚》(Allegiance)是讲述潜伏在美国的俄罗斯间谍的。哈。
It is just a common sense that no one wants to see chaos at his doorstep.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
“What happens if one of these Airbnb guests starts a fire?” asked Phyllis H. Weisberg, chairwoman of the Cooperative and Condominium Law Committee at the New York City Bar Association. “Who’s paying for that?”
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
As a brand, Acura sold 167,843 cars and trucks last year, a 1.5% increase. Lexus, Toyota’s premium brand, was up 13.7%; BMW was up 9.8%, Audi was up 15.2% and Mercedes-Benz was up 6.5% in a U.S. market that was very favorable for luxury vehicle manufacturers.
But I expect other banks to follow suit. Any effort to keep good people fresh and engaged, without paying them more, should be up for consideration.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
WTF.2: They Believe You Can Fly
The charges of Russian hacking and Mr Trump’s evident defects of experience, judgment and character show that the college has not proved the bulwark Mr Hamilton hoped for.
Detectives have laid charges, but said they will not release the details of the offenses until Friday when both the 18-year-old and the youth are expected to appear in court.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
During the same period, Braziland Russia slashed their holdings to USD 261.7 billion and USD 108.9 billion,respectively.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
“Yao represents the new wave of wealth creation by financial investments in China,” said Rupert Hoogewerf, who compiles the annual list.
'I think South Korea has a very rigorous and narrow definition of beauty because we’re an ethnically homogenous society and everyone looks pretty much the same. It is also related to low self-esteem.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Notably, among the nine schools ranked for the first time, WP Carey School of Business at the Arizona State University is the first US institution to take part in the ranking, having entered at 82.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Goldman Sachs will pay out big bonuses, be publicly vilified for a month and then go quietly back to printing profits.
Influenza neuraminidase: A druggable target for natural products
Leading the pack of the best airlines for holiday travel is Hawaiian Airlines, followed by another Pacific Coast-focused carrier, Alaska Airlines. Conversely, the worst airline for holiday travel is New York-based JetBlue Airways, with ExpressJet, a regional carrier, coming in next to last, according to the FlightAware data.
‘Our hope is that the Worst Passwords of the Year list will cause people to take steps to protect themselves online.’
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
用户说，语音信息的传输速度很快，可以在微信平台上对话。但和微软(Microsoft Corp.)的Skype等免费语音应用不同的是，在微信上还可以另选时间回复别人发来的语音信息。北京微信用户Robin Wang说，我可以决定什么时候回复，以及回不回复。
These collaborations signal a moment where the cradle of innovation and the arbiters of fashion are finally embracing one another, says L2 research director Colin Gilbert. Style is not the only missing piece to the wearable puzzle, but it’s something to look forward to, Gilbert says. More than half of the report’s respondents want devices that feel more like jewelry while 62 percent would like more than wrist-worn devices.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
That was in line with last month’s manufacturing PMIs, which showed an uptick in sector activity,
LONDON — In the 1970s, the British comedian Tommy Cooper used to tell a joke about asking an auction house to value a violin and a painting that he had discovered in an attic. The good news, he was told, is that they were made by Stradivarius and Rembrandt. The bad news was that the painting was by Stradivarius and the violin was by Rembrandt.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
"Shanghai has taken a series of tough measures to curb population growth since 2014, including renovating urban villages and regulating group renting," Zhou Haiwang, an expert with the Shanghai Academy of Social Sciences, told the Global Times.
We will perform with a strong work ethic, sense of responsibility, and enterprising spirit.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
1)Thank You: Common courtesy? Sure. But tell me this: When was the last time you forgot (or rejected) gratitude? Whether given in private or public, a sincere ‘thanks’ creates goodwill. Don’t forget your mother’s advice: “Say please.” People are always happier doing a favor than taking an order.
Inhibition of SARS coronavirus helicase by bismuth complexes
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The Great Recession had devastating effects across the U.S. and few places were as hard hit as Arizona. The state was booming on the strength of its tourism and real estate markets during the 2000s. Median home prices jumped 70% between 2003 and 2006—only Nevada had bigger gains—fueling more building and construction jobs. Monthly unemployment was at 3.5% through much of 2007. But then the bottom fell out. Home prices plummeted more than 50% from their peak and 6% Arizona properties received foreclosure filings in 2009. Unemployment stubbornly remained in double-figures for most of 2009 and 2010 and only Nevada lost a higher percentage of jobs over the last five years. Household incomes declined at the fastest rate in the country since 2008.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Slow growth around the world won't hurt the U.S. all that much. American exports might flatten out or even dip, but that would be offset by lower imports of petroleum because of sinking oil prices. So the trade deficit is unlikely to get further out of whack.
We are a group of twelve and thirteen-year-olds from Canada trying to make a difference:Vanessa Suttie, Morgan Geisler, Michelle Quigg and me. We raised all the money ourselves to come six thousand miles to tell you adults you must change your ways. Coming here today, I have no hidden agenda. I am fighting for my future. 我们是一个十三四岁的小群体，我们想改变些什么：Vanessa Suttie, Morgan Geisler, Michelle Quigg和我。我们自己挣钱支持我们来到这里，旅行5000英里只为告诉你们成年人，你们必须改变你们的生活方式。今天我来到这里，我背后没有任何经纪人，我们为我们的未来而战。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Whiteness means being part of the group whose appearance, traditions, religion and even food are the default norm. It’s being a person who, by unspoken rules, was long entitled as part of “us” instead of “them.”
"Hard to believe so many doctors lied in the papers. Can patients still trust them to help us treat diseases?" wrote one Sina Weibo user.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The deal makes a millionaire of 17-year-old Mr D’Aloisio, who taught himself to write software aged 12 and will join Yahoo’s London office while he continues his studies at school.
Earlier on Tuesday Mr Rutte had issued a call for calm in the dispute with Turkey.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Lady Gaga以5.9千万位列第四，其后是5.45千万的碧昂斯。前者在统计期间演出了66场，也靠与范思哲和MAC的合约获得收入，同时还有她自己的黑色香水。后者与其老公Jay Z的On The Run巡回演唱会通过19天（北美日期），赚得了超过10千万，创造了能与滚石相比较的第一对音乐界夫妻档夜平均的神话。
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The dollar value of outbound shipments from China rose 12.3 per cent year on year in November, lifting from a revised pace of 6.8 per cent in October, and smashing a median forecast of 5 per cent from economists polled by Reuters.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The first view is that the price is inherently cyclical. What has come down must go back up again and the deeper the trough the higher the next mountain.
NBS senior statistician Sheng Guoqing attributed the slowdown mainly due to a 1.4-percent decline in food prices, which were down for the first time in 15 years.
New Chinese firms on the list include Vanke, China Railway Engineering Corporation (CREC) and China Taiping Insurance.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Song “Happiness” (Mao A’Min)
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Ladies and gentlemen, may I welcome you to the Bad Manners Awards 2016?
出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
China has continued to synchronize enterprises and institutions to raise the basic pension for over 100m retirees in 2017.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Heatwaves around the world, including one in India that led to more than 2,000 deaths and another in Iraq that saw the mercury top 50C, helped push temperatures 1C above pre-industrial levels for the first time, US and UK researchers said.
A schoolgirl aged 11 has been honoured as "America's top young scientist" for inventing a quick, low-cost test to detect lead-contaminated water.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Since April 2007, the value of the top 100 brands has increased by 106 per cent. That compares with a 61 per cent rise in the S&P 500 and growth of 21 per cent in the MSCI world index over the same period.
Mr Mallaby accepted the award at a dinner in London on November 22, where the guest speaker was Dido Harding, chief executive of TalkTalk, the UK telecoms group.
Consoles: PlayStation 4
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
But the runaway winner was Ford CEO Mark Fields, who began the year with the depressing news that his company was “transitioning from an auto company to an auto company and a mobility company”. He then went on to declare: “Heritage is history with a future.” He was so chuffed with this, he said it more than once. On hearing it repeated, I’ve concluded it is less gnomic than downright moronic. Mr Fields is thus my new Chief Obfuscation Champion.
节目20 小品《今天的幸福2》，沈腾 马丽 杜晓宇 王琦
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The economy has registered a slower but stable performance with good momentum for growth.
A modular microarray imaging system for highly specific COVID-19 antibody testing
There was no immediate word from the Romney camp on the reported results。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
All this is happening before our eyes and yet we act as if we have all the time we want and all the solutions. I'm only a child and I don't have all the solutions, but I want you to realise, neither do you! 所有这一切就发生在我们眼前，然而我们还是一直向大自然无度索取我们所需要的。我仅仅是个孩子，我不知道该怎么办。 但我们这些孩子——这个星球的未来需要让您认识到，您不能说没办法！
The circular also stressed zero tolerance for cheating.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
We will make solid efforts to pursue the Belt and Road Initiative.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
GM Masai Ujiri struck twice to position Toronto for a second trip to the East finals, nabbing Ibaka from the Magic and Tucker from the Suns.
Their inclusion has come at the expense mainly of European companies, signalling the shift in economic power towards the east. There is only one Indian brand in the top 100 ranking — HDFC Bank. Russian, Mexican and Brazilian brands have fallen out of the ranking in the past few years — a sober reflection of the changing fortunes of these emerging markets.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
11. “The Black Panthers: Vanguard of the Revolution” (Stanley Nelson)
A facile assay for rapid detection of COVID-19 antibodies
"Machines will be stronger and smarter than human beings, but they will never be wiser," he said, "because one thing's for sure: Wisdom, soul and heart are things that only human beings possess, and machines can never enjoy failure, success, friendship or love."
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
3. Jeonju, South Korea-Hundreds of traditional Korean houses remain in central Jeonju's Hanok village.
6. China will also soonmake further announcements regarding affordable housing and more accessiblehealthcare. The country still needs 75 million more $75,000 housing unitsand it will begin breaking ground on them, in earnest, in 2014. Theseinvestments, particularly in health care, will effectively become self-funded,allowing average Chinese consumers to consider saving less, and spending more. It will drive longevity and years of productive employment.
UK schools account for more than a third of all graduates from the top 50 pre-experience programmes and not only attracted nearly half of all female students but also almost half of all international students. Indeed, 94 per cent of students enrolled in a UK MiF pre-experience programme in 2014 were from overseas. About 85 per cent of these students were from outside the European Economic Area, including 55 per cent of the overall number from mainland China.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
We learned about fetal surgery’s potential to change lives.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
*剧情类最佳客串女演员：玛格?马丁戴尔(Margo Martindale)，《美国谍梦》(The Americans)
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Sandy has caused large-scale damage, with more possibly to come.
Mr. Sissako is both an indispensable political filmmaker and one of the great poets of contemporary cinema. His portrait of life under jihadi rule in northern Mali is brutal and shocking, but also gentle, generous and surprisingly funny. Mr. Sissako does not humanize violent extremists so much as demonstrate that they already belong to the species and reflect part of our common, tragic nature. But his movie also insists that the only effective and ethically serious way to oppose fanaticism is with humanism. Which is to say with irony, with decency and, perhaps above all, with art. (Read the review.)
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
But if the U.S. can avert that Washington-made crisis, the outlook for workers finding jobs is actually looking pretty good for next year. For one thing, the damage of superstorm Sandy will have to be repaired, meaning jobs in construction and retail. Businesses, meanwhile, which have held off investing and hiring because of uncertainty over the fiscal outlook, might finally open their wallets. That means more jobs, too.[qh]
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
Pink, LeBron James, Selena Gomez, Ian Somerhalder, Jay-Z and Beyonce, Ben Affleckalso made the list.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
After the officials realized what had happened, they tried to get on stage immediately. But the news was broken to the La La Land cast and crew after they had started their acceptance speeches.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
“Since these developments will not fade overnight, there is little hope for a trade revival in 2017,” says Mr Leering.
"It is a truly a global phenomenon in which people, due to lack of opportunities, have to leave their families behind to provide for them," said Pedro De Vasconcelos, IFAD policy advisor and author of the report.
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